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Implications of the gut microbiome in cardiovascular diseases: Association of gut microbiome with cardiovascular diseases, therapeutic interventions and multi-omics approach for precision medicine
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  • Ramu Meenatchi,
  • Prabhakar Singh,
  • Z.H Tawfeeq Ahmed,
  • ASWIN THACHARODI,
  • Rohinth M,
  • REJITH RS KUMAR,
  • HARSHA VARTHAN M K,
  • SAQIB HASSAN
Ramu Meenatchi
SRM Institute of Science and Technology (Deemed to be University)
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Prabhakar Singh
Sathyabama Institute of Science and Technology (Deemed to be University)
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Z.H Tawfeeq Ahmed
Sathyabama Institute of Science and Technology (Deemed to be University)
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ASWIN THACHARODI
DEPARTMENT OF RESEARCH & DEVELOPMENT, DR. THACHARODI'S LABORATORIES
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Rohinth M
Sathyabama Institute of Science and Technology (Deemed to be University)
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REJITH RS KUMAR
Sathyabama Institute of Science and Technology (Deemed to be University)
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HARSHA VARTHAN M K
Sathyabama Institute of Science and Technology (Deemed to be University)
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SAQIB HASSAN
Sathyabama Institute of Science and Technology (Deemed to be University)

Corresponding Author:[email protected]

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Abstract

Cardiovascular diseases (CVDs) remain a major global health burden, and emerging evidence suggests that the gut microbiome plays a pivotal role in their pathogenesis and progression. This review paper aims to comprehensively analyze the intricate interplay between the gut microbiome and cardiovascular health. An extensive examination of existing literature explores how gut microbial composition and function influence CVD risk factors, such as inflammation, lipid metabolism, and blood pressure regulation. Additionally, we delve into the impact of dietary patterns, medications, and lifestyle factors on shaping the gut microbiota and how these changes can either exacerbate or ameliorate cardiovascular outcomes. Furthermore, we discuss the potential of gut microbiome-targeted interventions as promising avenues for preventing and managing CVDs. By consolidating the current state of knowledge, this review aims to shed light on the intricate link between the gut microbiome and cardiovascular diseases and highlights the potential for novel therapeutic strategies to combat this significant public health challenge.