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Recent Advances in Domino Synthesis of Polycyclic N-Heterocycles Based on Intramolecular Alkyne Hydroamination under Copper Catalysis
  • Xin Lv,
  • Zefeng Jin,
  • Guodong Shen
Xin Lv
Zhejiang Normal University

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Zefeng Jin
Zhejiang Normal University
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Guodong Shen
Liaocheng University
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Polycyclic N-heterocycles are very important scaffolds in biomedicinal chemistry and materials science. Intramolecular alkyne hy-droamination is a powerful method for the construction of N-heterocycles. In the last two decades, copper-catalyzed domino reac-tions based on intramolecular alkyne hydroamination has emerged as a robust strategy for assembling various polycyclic N-heterocycles. Great progress has been achieved in this area. This short review covers the advances made in copper-catalyzed domino synthesis of polycyclic N-heterocycles based on this strategy from 2008 to 2023, and will hopefully serve as an inspiration towards the exploration of new copper-catalyzed versions of the transformation. The domino transformations are introduced and discussed from five aspects according to the different key processes involved in these reactions.
25 Aug 20231st Revision Received
31 Aug 2023Assigned to Editor
31 Aug 2023Submission Checks Completed
31 Aug 2023Review(s) Completed, Editorial Evaluation Pending
31 Aug 2023Editorial Decision: Accept