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Comparative Evaluation of Bone Marrow and Dental Pulp Mesenchymal Stem Cells for Motor Functional Recovery in Rat Sciatic Nerve Injury
  • ELGİN ORÇUM UZUNLU,
  • Zeki OGURTAN
ELGİN ORÇUM UZUNLU
Selcuk Universitesi

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Zeki OGURTAN
Selcuk Universitesi
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Abstract

This article investigates the effects of bone marrow-derived mesenchymal stem cells (BM-MSCs) and dental pulp-derived mesenchymal stem cells (DP-MSCs) on motor functional recovery and morphological parameters of the sciatic nerve in rats with crushing injuries. The results showed that the BM-MSCs, DP-MSCs, and BM +DP-MSCs groups exhibited increased SFI values compared to the sham group, indicating improved motor function. Histomorphological analysis revealed preserved perineurium structure and fascicular organization in all groups, with minimal irregularities in the sham and BM-MSCs groups. Vascular density was normal in all groups, and edema and inflammatory cell density were reduced in the BM +DP-MSCs group. Immunohistochemical staining showed S100 expression in all treated groups. The study concludes that BM-MSCs, DP-MSCs, and their combination can effectively promote motor functional recovery and morphological improvements.