Immune receptors involved in non-polio enterovirus
AbstractNon-polio enterovirus such as EV-D68 and EV-A71 has been reported to
cause a polio-like neurological disease known as acute flaccid myelitis.
One of the diagnostics of acute flaccid myelitis is robust inflammation
in cerebrospinal fluid. This may be due to the immune response triggered
by EV-D68 and EV-A71 causing an influx of pro-inflammatory mediators to
the infection site resulting in neurological disease. In order to reduce
or prevent inflammation in the infection site, the mechanism and
pathways of the immune response against EV-D68 and EV-A71 are important.
Immune receptors are the sensor and the most important step to initiate
the immune response. Pattern recognition receptors and inflammasome
receptors are the main receptors to detect viruses including
enterovirus. It is important to understand the mechanism and pathways
receptors are involved.