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A rare case of metaplastic breast carcinoma from India: Towards precision oncology
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  • Soirindhri Banerjee,
  • Ishika Mahajan,
  • Aruni Ghose,
  • Stergios Boussios,
  • Shivam Chakraborty
Soirindhri Banerjee
IPGMER

Corresponding Author:[email protected]

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Ishika Mahajan
Lincoln County Hospital
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Aruni Ghose
Barts Health NHS Trust
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Stergios Boussios
Medway NHS Foundation Trust
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Shivam Chakraborty
IPGMER
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Abstract

Background : Metaplastic Breast Cancer (MpBC) is an exceedingly rare entity, accounting for less than 1% of all malignant breast tumours. Predominantly triple-negative, they are notorious for their chemoresistance, high rates of recurrence and decreased disease-free survival (DFS). All this contributes significantly to BC mortality and results in poor prognostic implications. Limited evidence has led to a lacuna of specific treatment guidelines for this entity and hence remains an uncharted territory for clinicians. Case : We report a case of left-sided low-grade metaplastic triple negative T3N2aM0 BC treated with neoadjuvant chemotherapy, primary surgery, and adjuvant radiotherapy, presently in remission. Conclusion : Limited experience in management of this pathological entity warrants the need for more research on it, with a special focus on targeted therapy. Discussing possibilities of a tailored approach, rather than a one-size-fits-all approach may aid in paving the path for the future of MpBC treatment.
02 Aug 2023Submitted to Cancer Reports
03 Aug 2023Review(s) Completed, Editorial Evaluation Pending
03 Aug 2023Submission Checks Completed
03 Aug 2023Assigned to Editor
15 Aug 2023Reviewer(s) Assigned
26 Oct 2023Editorial Decision: Revise Major
10 Nov 20231st Revision Received
11 Nov 2023Submission Checks Completed
11 Nov 2023Assigned to Editor
11 Nov 2023Review(s) Completed, Editorial Evaluation Pending
11 Nov 2023Reviewer(s) Assigned