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Physiology of GPCRs in the nervous system and the contribution of orphan GPCRs
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  • Necla Birgül Iyison,
  • Clauda Abboud,
  • Dayana Abboud,
  • Abdulrasheed Abdulrahman,
  • Ana-Nicoleta Bondar,
  • Julie Dam,
  • Dogan Soner,
  • Zafiroula Georgoussi,
  • Jesus Giraldo,
  • Anemarie Horvat,
  • Christos Karoussiotis,
  • Meliha Karsak,
  • Alba Castro,
  • Miriam Scarpa,
  • Hannes Schihada,
  • Nicole Scholz,
  • Bilge Guvenc Tuna,
  • Jan Vacek,
  • Nina Vardjan
Necla Birgül Iyison
Bogazici University Faculty of Arts and Sciences

Corresponding Author:[email protected]

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Clauda Abboud
University of Liege
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Dayana Abboud
University of Liege
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Abdulrasheed Abdulrahman
INSERM
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Ana-Nicoleta Bondar
Forschungszentrum Jülich GmbH
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Julie Dam
INSERM
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Dogan Soner
Yeditepe University School of Medicine
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Zafiroula Georgoussi
Natl Ctr Sci Res Demokritos
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Jesus Giraldo
Universitat Autònoma de Barcelona
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Anemarie Horvat
University of Ljubljana Faculty of Medicine
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Christos Karoussiotis
National Centre for Scientific Research-Demokritos
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Meliha Karsak
University of Hamburg Faculty of Medicine
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Alba Castro
Universidade de Santiago de Compostela
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Miriam Scarpa
Karolinska Institute Department of Clinical Neuroscience
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Hannes Schihada
University of Marburg Faculty of Pharmacy
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Nicole Scholz
University of Leipzig Faculty of Medicine
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Bilge Guvenc Tuna
Yeditepe University School of Medicine
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Jan Vacek
Palacky University Olomouc
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Nina Vardjan
University of Ljubljana, Slovenia
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Abstract

G protein-coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important drug targets. In this review, we will first discuss the role of the nervous system GPCRs in the modulation of tripartite synapse function and how GPCRs control energy metabolism in the brain. We will then discuss the (patho)physiology and pharmacology of opioid, cannabinoid, acetylcholine, chemokine, and melatonin GPCRs in the nervous system. Furthermore, we will briefly report on adhesion GPCR function in nervous tissues. Finally, we will address orphan GPCRs, their implication in the nervous system function and disease, and the challenges that need to be addressed in the future to deorphanize them.
31 Jul 2023Submitted to British Journal of Pharmacology
01 Aug 2023Assigned to Editor
01 Aug 2023Submission Checks Completed
01 Aug 2023Reviewer(s) Assigned
20 Aug 2023Review(s) Completed, Editorial Evaluation Pending
28 Aug 2023Editorial Decision: Revise Minor