loading page

Targeting accelerated pulmonary ageing to treat COPD induced neuropathological comorbidities.
  • Simone De Luca,
  • Ross Vlahos
Simone De Luca
RMIT University
Author Profile
Ross Vlahos
RMIT University

Corresponding Author:[email protected]

Author Profile


Chronic Obstructive Pulmonary Disease (COPD) is a major incurable health burden, ranking as the 3rd leading cause of death worldwide, mainly driven by cigarette smoking. COPD is characterised by persistent airway inflammation, lung function decline, and premature aging with the presence of pulmonary senescent cells. This review proposes that cellular senescence, a state of stable cell cycle arrest linked to ageing; induced by inflammation and oxidative stress in COPD, extends beyond the lungs and impacts the systemic circulation. This “spill over” of senescent cells contributes to brain inflammation and damage, increasing the risk of neurological comorbidities, such as stroke, cerebral small vessel disease, and Alzheimer’s disease. The review explores the role of cellular senescence in COPD-associated brain conditions and investigates the relationship between cellular senescence and circadian rhythm in COPD. Additionally, it discusses potential therapies, including senomorphic and senolytic treatments, as novel strategies to halt or improve COPD progression.
27 Jul 2023Submitted to British Journal of Pharmacology
27 Jul 2023Submission Checks Completed
27 Jul 2023Assigned to Editor
27 Jul 2023Reviewer(s) Assigned
11 Aug 2023Review(s) Completed, Editorial Evaluation Pending
13 Aug 2023Editorial Decision: Revise Minor
07 Sep 20231st Revision Received
07 Sep 2023Submission Checks Completed
07 Sep 2023Assigned to Editor
09 Sep 2023Reviewer(s) Assigned
14 Sep 2023Review(s) Completed, Editorial Evaluation Pending
27 Sep 2023Editorial Decision: Accept