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The Role of Long Non-Coding RNA ZFAS1 in Gliomagenesis: A Scoping Review
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  • Amirah Abdul Rahman,
  • Engku Maryam Afifah Engku omarAmiruddin,
  • Muhammad Fawwaz Mohd Usoff,
  • Siti Hamimah Sheikh Abdul Kadir,
  • Kamariah Ibrahim,
  • Nora Julianna Osman
Amirah Abdul Rahman
Universiti Teknologi MARA Kampus Sungai Buloh

Corresponding Author:[email protected]

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Engku Maryam Afifah Engku omarAmiruddin
Universiti Teknologi MARA Kampus Sungai Buloh
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Muhammad Fawwaz Mohd Usoff
Universiti Teknologi MARA Fakulti Sains Gunaan
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Siti Hamimah Sheikh Abdul Kadir
Universiti Teknologi MARA Kampus Sungai Buloh
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Kamariah Ibrahim
Universiti Malaya Department of Biomedical Science
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Nora Julianna Osman
Universiti Teknologi MARA Kampus Sungai Buloh
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Abstract

Non-coding RNA species play important roles in biological mechanisms that regulate glioma initiation and progression. Recently, evidence suggests that ZNFX1 antisense RNA 1 ( ZFAS1) has the ability to act as an oncogene or tumour suppressor, and so plays critical regulatory functions in the development and progression of many types of cancers such as lung, renal and hepatocarcinoma. The roles of ZFAS1 in glioma cancer are still unclear, and there are numerous potential pathways to explore. The current work provides a scoping review of studies on ZFAS1’s functions and underlying molecular mechanisms in the initiation and progression of glioma, as well as a possible field of research to be examined further. A literature search was carried out using Scopus, PubMed, and Web of Science (WoS) using a specified search string, and the data gathered was discussed and reported. This scoping review comprised five original research papers that study ZFAS1 and its roles in gliomagenesis. ZFAS1 was found to be highly upregulated in glioma. Tumour-node-metastasis (TNM) stage, lymph node metastases, and overall survival were revealed to be significantly associated with ZFAS1 status and regulated via several pathways and interactions, such as miRNA signalling, Epithelial-to-Mesenchymal Transition (EMT) and Notch signalling pathway. Furthermore, ZFAS1 knockdown decreased cell proliferation, migration, and invasion while promoting cell death, implying that ZFAS1 is involved in the glioma cancer progression. The evaluation of their diagnostic importance and therapeutic potential may aid in the development of novel therapies for glioma cancer.
21 Jul 2023Submitted to Cell Biochemistry & Function
25 Jul 2023Assigned to Editor
25 Jul 2023Submission Checks Completed
25 Jul 2023Review(s) Completed, Editorial Evaluation Pending
02 Aug 2023Reviewer(s) Assigned
07 Sep 2023Editorial Decision: Revise Major