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Temprospatial Dynamics of the Morphogenesis of the Rabbit Retina from Prenatal to Postnatal Life: Light, Immunohistochemical and Electron Microscopic Study
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  • Nagwa Ibrahim,
  • Sara M. M. El-Desoky,
  • Ruwaida Elhanbaly,
  • Abdalla Hifny,
  • Wafaa Gaber
Nagwa Ibrahim
Assiut University Faculty of Veterinary Medicine

Corresponding Author:[email protected]

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Sara M. M. El-Desoky
Assiut University Faculty of Veterinary Medicine
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Ruwaida Elhanbaly
Assiut University Faculty of Veterinary Medicine
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Abdalla Hifny
Assiut University Faculty of Veterinary Medicine
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Wafaa Gaber
Assiut University Faculty of Veterinary Medicine
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Abstract

The retina consists of various cell types arranged in eight cell layers and two membranes that originate from the neuroectodermal cells. The purpose of this study is to evaluate the morphogenesis of the retina by using light and electron microscopy, as well as immunohistochemical techniques. The timing of differentiation and distribution of the cellular component and the layers of the rabbit retina are investigated. There were 32 rabbit embryos and 12 rabbits used. The rabbit retina begins its prenatal development on the tenth day of gestation in the form of optic cup. The process of neuro- and glio-genesis occurs in several stages; in the first stage, the ganglionic cells are differentiated. The second stage includes the differentiation of Muller, amacrine and cone cells. The differentiation of bipolar, horizontal and rod cells consider the late stage of neuro-genesis. All these stages occur during the embryonic period. Then the retina continues its development postnatally by formation of the outer segment of photoreceptor layer and the all layers of the rabbit retina are established. By immunohistochemical studies, the S100 protein is expressed by the Muller cells that locate in the inner nuclear layer and its radiating processes that traverse the retina from the outer to the inner limiting membranes. Concerning to Calretinin, it is labeled within the amacrine cells which occupy the inner nuclear layer and the displaced amacrine cells that locate in the ganglionic cell layer.