loading page

TAFRO Syndrome, An Uncommon Presentation in a Pediatric Patient
  • +3
  • Amanda Walker,
  • Sarah Saad,
  • Suchitra Sangappa,
  • Harini Rao,
  • Teena Bhatla,
  • Surabhi Batra
Amanda Walker
Rutgers New Jersey Medical School

Corresponding Author:[email protected]

Author Profile
Sarah Saad
Children's Hospital of New Jersey at Newark Beth Israel Medical Center
Author Profile
Suchitra Sangappa
Children's Hospital of New Jersey at Newark Beth Israel Medical Center
Author Profile
Harini Rao
Children's Hospital of New Jersey at Newark Beth Israel Medical Center
Author Profile
Teena Bhatla
Children's Hospital of New Jersey at Newark Beth Israel Medical Center
Author Profile
Surabhi Batra
Children's Hospital of New Jersey at Newark Beth Israel Medical Center
Author Profile

Abstract

TAFRO syndrome involves a constellation of symptoms including thrombocytopenia, anasarca, fever, reticulin fibrosis and organomegaly. It was first described in 2010 as a subtype of idiopathic Multicentric Castleman’s Disease (iMCD). This report describes an atypical presentation in a 12-year-old male who suffered significant morbidity and was eventually diagnosed with TAFRO syndrome. Due to overlapping characteristics with other autoimmune processes and paucity of literature in pediatrics, TAFRO syndrome could present as a diagnostic dilemma to pediatric hematologists and pediatricians. Early recognition and timely treatment can help prevent significant morbidity as noted in our patient.