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Central Nervous System Metastases in Pediatric Patients with Ewing Sarcoma
  • +2
  • Leonora Slatnick,
  • Carrye Cost,
  • Timothy Garrington,
  • Nathan Donaldson,
  • Margaret Macy
Leonora Slatnick
The University of Utah Department of Pediatrics

Corresponding Author:[email protected]

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Carrye Cost
University of Colorado Anschutz Medical Campus Department of Pediatrics
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Timothy Garrington
University of Colorado Anschutz Medical Campus Department of Pediatrics
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Nathan Donaldson
University of Colorado Anschutz Medical Campus
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Margaret Macy
University of Colorado Anschutz Medical Campus Department of Pediatrics
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Abstract

Metastatic central nervous system (CNS) involvement is rare in pediatric primary extracranial Ewing sarcoma (ES). We describe the incidence and course of six patients with extracranial ES who developed metastatic CNS lesions treated at a single institution. Median time to CNS disease detection was 16.3 months (10.0-28.3 months). Event free and overall survival after CNS disease detection were 1.9 months (0.4-10.3 months) and 4.6 months (1.1-50.9 months), respectively. One patient was alive at the time of analysis. Clinical status and ability to obtain disease control should be considered when making decisions regarding aggressive interventions in these patients with poor prognosis.