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Comparison of PD-L1 Expression in Squamous Cell Carcinoma and Adenocarcinoma of the Cervix in Paraffin Blocks of cervical cancer patients
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  • Maryam Sadat Hosseini,
  • Fatemeh Shafizadeh,
  • Mohammad Hashemi Bahremani,
  • Farah Farzaneh,
  • Tahereh Ashrafganjoei,
  • Maliheh Arab,
  • Maryam Talayeh,
  • Fatemeh Jafari,
  • Alireza Abdshah
Maryam Sadat Hosseini
Shahid Beheshti University of Medical Sciences
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Fatemeh Shafizadeh
Shahid Beheshti University of Medical Sciences

Corresponding Author:[email protected]

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Mohammad Hashemi Bahremani
Shahid Beheshti University of Medical Sciences
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Farah Farzaneh
Shahid Beheshti University of Medical Sciences
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Tahereh Ashrafganjoei
Shahid Beheshti University of Medical Sciences
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Maliheh Arab
Shahid Beheshti University of Medical Sciences
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Maryam Talayeh
Shahid Beheshti University of Medical Sciences
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Fatemeh Jafari
Tehran University of Medical Sciences Cancer Research Center
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Alireza Abdshah
Tehran University of Medical Sciences School of Medicine
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Abstract

Introduction: Cervical cancer, predominantly caused by human papillomavirus (HPV), is a common malignancy in women. Distinct histological subtypes, such as squamous cell carcinomas (SCC) and adenocarcinomas (AC), exhibit different characteristics and treatment responses. Immune checkpoint molecules, including programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1), contribute to immune evasion. This study aims to investigate PD-L1 expression in SCC and AC of cervix and explore its association with clinical features. Methods: This cross-sectional study was conducted on samples from 2016 to 2022 in Shahid Beheshti University of Medical Sciences-affiliated hospitals, Tehran, Iran. Paraffin-embedded samples of histologically confirmed cervical cancers (48 SCC - 16 AC) were analyzed, and clinical data were extracted from medical records. PD-L1 expression was assessed using immunohistochemistry, and the combined positive score was utilized. Statistical analyses included T-tests, Chi-Square tests, and non-parametric equivalents. Results: PD-L1 expression tended to be higher in SCC cases, although the difference was not statistically significant. Positive PD-L1 expression was more common in SCC cases. However, no significant correlation was observed between PD-L1 expression and clinical features in either subgroup. Mean age and clinical characteristics did not significantly differ between the SCC and AC groups. Conclusion: This study investigated PD-L1 expression in SCC and AC of the cervix and its relationship with clinical features. Although SCC cases tended to exhibit higher PD-L1 expression, the difference was not statistically significant. Further research is warranted to elucidate the role of PD-L1 in cervical cancer and its potential implications for immunotherapy.
04 Jul 2023Submitted to Cancer Reports
12 Jul 2023Submission Checks Completed
12 Jul 2023Assigned to Editor
18 Jul 2023Review(s) Completed, Editorial Evaluation Pending
19 Jul 2023Reviewer(s) Assigned
12 Sep 2023Editorial Decision: Revise Major
10 Nov 20231st Revision Received
11 Nov 2023Submission Checks Completed
11 Nov 2023Assigned to Editor
11 Nov 2023Review(s) Completed, Editorial Evaluation Pending
15 Nov 2023Reviewer(s) Assigned