Title Successful Prenatal Treatment with Continuous Chronic Maternal
Hyperoxygenation Therapy in Hypoplastic Left Heart in Two Pregnancies:
ABSTRACT Maternal hyperoxygenation (MH) has been studied as a
diagnostic tool to evaluate pulmonary vasculature and as a treatment
option to improve the growth of fetal left heart in fetuses with
left-sided cardiac defects. Chronic maternal hyperoxygenation (CMH)
therapy leads to an improvement in fetal pulmonary blood flow resulting
in an enhanced venous return to the left heart with increased
gestational age. With this manipulation it is anticipated to augment
blood flow directed remodeling of the left heart structures and to
improve left heart growth spanning from the mitral valve to the aortic
isthmus. However, there are concerns about CMH therapy with regard to
fetal complications with growth restriction and fetal brain development.
Now, with two successful cases we try to discuss this fetal treatment
option and related concerns.