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Effect of injectable calcium alginate-amelogenin hydrogel on macrophage polarization and promotion of jaw bone osteogenesis
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  • Tingting Zhao,
  • Luyuan Chen,
  • Gang He,
  • Chengcheng Yu,
  • Huajun Lin,
  • Zhihui Chen,
  • Yonglong Hong,
  • Wen Sui,
  • Jianjiang Zhao
Tingting Zhao
Southern Medical University
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Luyuan Chen
Shenzhen Hospital of Southern Medical University
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Gang He
Southern Medical University
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Chengcheng Yu
Shenzhen Hospital of Southern Medical University
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Huajun Lin
Shenzhen Hospital of Southern Medical University
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Zhihui Chen
Shenzhen Hospital of Southern Medical University
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Yonglong Hong
Shenzhen Hospital of Southern Medical University
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Wen Sui
Shenzhen Technology University
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Jianjiang Zhao
Southern Medical University

Corresponding Author:[email protected]

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Abstract

To investigate the effect of an injectable calcium alginate-amelogenin hydrogel on the polarizability of macrophages and its mechanism of effectively mediating the bone immune microenvironment and improving the osteogenic efficacy of jaw and facial bone defect areas. In this study, we prepared an injectable calcium alginate-amelogenin hydrogel using calcium alginate loaded with amelogenin and investigated its physical properties through cellular experiments. The experimental results showed that the material is injectable, biocompatible, degradable, anti-inflammatory, and promotes osteogenesis. This project provides new ideas for formulating bone tissue regeneration materials and promotes their clinical translation.