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Narrow Band Imaging reveals field cancerisation undetected by conventional White Light: optical diagnosis versus histopathology
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  • Jeroen Westra,
  • Manon Zwakenberg,
  • Gyorgy Halmos,
  • Bernard van der Laan,
  • Bert van der Vegt,
  • Boudewijn Plaat
Jeroen Westra
Universiteit Groningen Department of Otorhinolaryngology

Corresponding Author:[email protected]

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Manon Zwakenberg
Universiteit Groningen Department of Otorhinolaryngology
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Gyorgy Halmos
Universiteit Groningen Department of Otorhinolaryngology
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Bernard van der Laan
Universiteit Groningen Department of Otorhinolaryngology
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Bert van der Vegt
Universitair Medisch Centrum Groningen Pathologie en Medische Biologie
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Boudewijn Plaat
Universiteit Groningen Department of Otorhinolaryngology
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Abstract

Objective To assess whether narrow band imaging (NBI) detects fields of cancerisation around suspicious lesions in the upper aerodigestive tract, which were undetected by white light imaging (WLI). Method In 96 patients with laryngeal and pharyngeal lesions suspicious for malignancy, 206 biopsies were taken during laryngoscopy: 96 biopsies of suspicious lesions detected by both WLI and NBI (WLI+/NBI+), 60 biopsies adjacent mucosa only suspicious with NBI (WLI-/NBI+), and 46 biopsies of NBI and WLI unsuspicious mucosa (WLI-/NBI-) as negative controls. Optical diagnosis according to the Ni-classification was compared with histopathology. Results Signs of (pre)-malignancy were found in 88% of WLI+/NBI+ biopsies, 32% of WLI-/NBI+ biopsies, and 0% in WLI-/NBI- (p <.001). In 58% of the WLI-/NBI+ mucosa any form of dysplasia or carcinoma was detected. Conclusion The use of additional NBI led to the detection of (pre)-malignancy in 32% of the cases, that would have otherwise remained undetected with WLI alone. This highlights the potential of NBI as a valuable adjunct to WLI in the identification of suspicious lesions in the upper aerodigestive tract.
21 Jun 2023Submitted to Clinical Otolaryngology
21 Jun 2023Submission Checks Completed
21 Jun 2023Assigned to Editor
26 Jul 2023Reviewer(s) Assigned
10 Sep 2023Review(s) Completed, Editorial Evaluation Pending
21 Sep 2023Editorial Decision: Revise Minor
21 Oct 20231st Revision Received
27 Oct 2023Assigned to Editor
27 Oct 2023Submission Checks Completed