Palladium-catalyzed denitrogenative self-carbonylation of arylhydrazine
using CO and O2 as an ideal oxidant
An efficient Pd/Cu-catalyzed oxidative self-carbonylation of
arylhydrazine with CO and molecular oxygen as an oxidant to afford
symmetrical biaryl ketones via C-N bond activation has been developed.
In this approach, arylhydrazine hydrochlorides are used as a green
arylating agent which releases nitrogen and water as a byproduct. This
developed protocol significantly restricts the for-mation of aryl iodide
and homo-coupled azobenzene products even under favorable conditions. A
library of symmetrical biaryl ke-tones with wide functionalities was
synthesized in good yields under mild conditions.