loading page

Atopy in Chronic Urticaria: An Important yet Overlooked Issue
  • +1
  • Qiquan Chen,
  • Xianjie Yang,
  • Bing Ni,
  • Zhi Song
Qiquan Chen
Third Military Medical University Southwest Hospital
Author Profile
Xianjie Yang
Third Military Medical University Southwest Hospital
Author Profile
Bing Ni
Army Medical University
Author Profile
Zhi Song
Third Military Medical University Southwest Hospital

Corresponding Author:[email protected]

Author Profile

Abstract

Chronic urticaria (CU) is a common clinical disease that seriously affects the quality of life of patients, but its pathogenesis is still not fully understood. The autoimmunity of chronic spontaneous urticaria (CSU) has been highly concerned and intensively studied in the past. Atopy is also one of the important characteristics of CU, but it has not been fully recognized. Atopy is a predisposition to respond immunologically to allergens, leading to type 2 inflammation and overproduction of immunoglobulin E (IgE). Compared with the healthy population, patients with CU have a higher proportion of atopy, and atopic background is correlated with the clinical characteristics of CU. The total IgE level of CU patients is significantly higher than that of healthy people. Although it is not higher than that of classic allergic diseases, its level is also closely related to CU. Exogenous allergens, autoallergens and their specific IgE, which are closely related to atopy, have been gradually discovered in CU, and their roles in the pathogenesis of CU are also being studied. Atopic inflammation is equally present in CU, both locally and systemically. This review summarizes up-to-date knowledge regarding atopy and CU, and speculates that atopic CSU or atopic CIndU indeed exists, providing a fresh perspective for comprehensively understanding the clinical characteristics of CU and further studying its pathogenesis.