Red Cell Transfusions in Children with Thalassemia; Outcomes of
a10mL/kg/hr Infusion Rate
Children with transfusion dependent thalassemia have an impaired ability
to synthesize alpha or beta globin which results in anemia. Packed red
blood cell (PRBC) transfusions are required to increase hemoglobin which
supports appropriate growth and development. PRBC transfusions must be
completed with 4 hours however infusion rates vary across institutions.
Our institution infuses PRBC’s up to 10mL/kg/hr. A descriptive study of
21 children who received a total of 276 transfusions during 2021
demonstrated that this rate is safe and well tolerated. Shorter
transfusion times support patients’ and families’ time, resources, and
quality of life and aptly utilize institutional resources.