loading page

To evaluate role of Neutrophil to lymphocyte ratio and Platelet to Lymphocyte ratio as diagnostic marker in children with acute exacerbation of bronchial asthma.
  • +1
  • Vivek Parihar,
  • Timmaraddi Hosamani D,
  • Ghanshyam Singh Sengar,
  • Dr.Mukesh Beniwal
Vivek Parihar
Sardar Patel Medical College

Corresponding Author:[email protected]

Author Profile
Timmaraddi Hosamani D
Sardar Patel Medical College
Author Profile
Ghanshyam Singh Sengar
Sardar Patel Medical College
Author Profile
Dr.Mukesh Beniwal
Sardar Patel Medical College
Author Profile

Abstract

Objective- To study the clinical significance of Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR) in the diagnosis of acute exacerbation of Bronchial Asthma Methods- This hospital-based observational cross-sectional study was conducted on the patients presenting to the Department of Paediatrics from August 2021 to August 2022. All children aged 5 to 15 years with bronchial asthma were included in the study fulfilling the inclusion criteria, and equal number of age and sex-matched controls were taken. NLR and PLR were compared between cases and controls. Results- The study included 122 cases and an equal number of age and sex-matched controls. The majority of cases were in the age group 5-7 years (59.0%). There were 51.6% female and 48.4% male cases. The mean NLR of cases with acute exacerbation of asthma was significantly higher than controls( 5.0±3.6 for cases and 1.3±0.6 for controls) (p=0.002). Mean NLR declined significantly at 3 months (1.4±0.5) after recovery. The PLR of cases with acute exacerbation of asthma was also significantly higher than controls (Mean 161.4±71.4 for cases and 100.8±57.2 for controls) (p=0.02) and significantly declined at 3 months of follow-up (Mean 97.5±47.2). NLR is a better marker with a diagnostic accuracy of 89.4% followed by PLR (76.3%). On ROC analysis acute exacerbation of asthma was indicated by NLR with maximum sensitivity of 83.60% and maximum specificity of 73.80%. Conclusion-NLR and PLR increased significantly during exacerbation of asthma and declined significantly at 3 months follow-up after recovery. These tests being low cost, easy to perform and widely available could be very useful in the management of Paediatric Asthma.