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Hei-Xiao-Yao-San improves amyloid plague in Alzheimer’s disease mice by regulating the PERK/CHOP pathway.
  • +3
  • Hongyan Wu,
  • Wang Yale,
  • Cui Shumei,
  • Li Guiyun,
  • Liu Donggui,
  • Wan Xianming
Hongyan Wu
Shanghai University of Traditional Chinese Medicine

Corresponding Author:[email protected]

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Wang Yale
Shanghai University of Traditional Chinese Medicine
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Cui Shumei
Dingxi Traditional Chinese Medicine Hospital
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Li Guiyun
Shanghai University of Traditional Chinese Medicine
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Liu Donggui
Shanghai University of Traditional Chinese Medicine
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Wan Xianming
Shanghai University of Traditional Chinese Medicine
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Abstract

Amyloid plaques and neurofibrillaric tangles are pathological characteristics of Alzheimer’s disease (AD). Endoplasmic reticulum stress (ERS) is involved in the neuron loss of AD. The aim of this study is to improve the amyloid plaques in an AD mouse model using Hei-Xiao-Yao-San (HXYS), a Chinese traditional medical formula. A mouse AD model was established. AD mice (APP/PS1 mice) were treated with HXYS or saline. Cognitive function in mice was evaluated by using the Morris water maze. The histology of the hippocampus was evaluated by hematoxylin eosin (H&E) staining. The ultra-structure of the hippocampal tissue was observed under a transmission electron microscope.Treatment with HXYS significantly enhanced cognitive function in AD mice. Neural loss and synaptic plasticity of the hippocampus were significantly improved. The amounts of APP (amyloid-beta precursor protein) and ERS associated proteins (CHOP and PERK) in the hippocampus were significantly reduced in AD mice. HXYS may enhance cognitive function in AD mice by regulating ERS.