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Self-assembly multifunctional DNA Tetrahedron for Efficient Elimination of Antibiotic-Resistant Bacteria
  • Yuhui Liao
Yuhui Liao
Southern Medical University

Corresponding Author:[email protected]

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Antibiotic resistance is a major challenge in the clinical treatment of bacterial infectious diseases. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier for bacteria-specific delivery of clinical antibiotic ciprofloxacin (CIP) and classic nanoantibiotic silver nanoparticles (AgNP). In our rational design, CIP was efficiently loaded in the self-assembly double-bundle DNA tetrahedron through intercalation with DNA duplex, and single-strand DNA-modified AgNP was embedded in the cavity of the DNA tetrahedron through hybridization. With the site-specific assembly of targeting aptamer in the well-defined DNA tetrahedron, the bacteria-specific dual-antibiotic delivery system exhibited excellent combined bactericidal properties. With enhanced antibiotic accumulation through breaking the out membrane of bacteria, the antibiotic delivery system effectively inhibited biofilm formation and promoted the healing of infected wounds in vivo. This DNA-based antibiotic delivery system provides a promising strategy for the treatment of antibiotic-resistant infections.
31 May 2023Submitted to Aggregate
01 Jun 2023Submission Checks Completed
01 Jun 2023Assigned to Editor
02 Jun 2023Reviewer(s) Assigned
20 Jun 2023Review(s) Completed, Editorial Evaluation Pending
21 Jun 2023Editorial Decision: Revise Major
16 Jul 20231st Revision Received
18 Jul 2023Submission Checks Completed
18 Jul 2023Assigned to Editor
18 Jul 2023Reviewer(s) Assigned
27 Jul 2023Review(s) Completed, Editorial Evaluation Pending
28 Jul 2023Editorial Decision: Accept