Marburg Virus Disease Outbreaks in Equatorial Guinea and Tanzania:
challenges and recommendations
The current outbreak of Marburg Virus in Equatorial Guinea and Tanzania
is a growing concern in Sub-Saharan African Region. With a mortality
rate of upto 88%, lack of treatment and its transmissibility, it has a
very high epidemic and pandemic potential. Unrestricted traveling can
result in a global pandemic with ease. The virus is transmitted mainly
via blood, skin puncture and fomites with secretions of an infected
person or Rousette bat colonies. The symptoms are divided into three
phases similar to the ebola virus. The average incubation period is
about 5-9 days. Many experimental drugs are being developed revealing
positive results like Favipravir (antiviral) and MR191-N (monoclonal
antibody). Pre-exposure vaccines are currently in Phase 1 clinical
trials. Post-exposure vaccines have also shown positive outcomes.
Stakeholders within countries should take action with strong commitment
by following instructions and warnings issued by WHO.