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Omentum provides a special cell microenvironment for ovarian cancer
  • Zeying Li,
  • Xiaoling Fang,
  • Sixue Wang
Zeying Li
Central South University
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Xiaoling Fang
Central South University

Corresponding Author:[email protected]

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Sixue Wang
Central South University
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Ovarian cancer seriously threatens women’s health because of its poor prognosis and high mortality. Due to the lack of efficient early detection and screening methods, when patients seek doctors’ help with complaints of abdominal distension, back pain and other nonspecific signs, the clinical results always hint at the widespread metastasis of disease. When referring to the metastasis of this disease, the omentum always takes precedence. The distinguishing feature of the omentum is adipose tissue, which satisfies the energy demand of cancer cells and supplies a more aggressive environment for ovarian cancer cells. In this review, we mainly focus on three important cell types: adipocytes, macrophages and mesenchymal stem cells. Besides, several mechanisms underlying cancer-associated adipocytes (CAA)-facilitated ovarian cancer cell development have been revealed, including their capacities for storing lipids and endocrine function, and the release of hormones, growth factors, and adipokines. Blocking the reciprocity among cancer cells and various cells located on the omentum might contribute to ovarian cancer therapy. The inhibition of hormones, growth factors and adipokines produced by adipocytes will be a novel therapeutic strategy. However, a sufficient number of trials has not been performed. In spite of this, the therapeutic potential of metformin and the roles of exercise in ovarian cancer will be worth mentioning. It’s almost impossible to overcome completely ovarian cancer at the moment. What we can do is trying our best to improve these patients’ prognoses. In this process, adipocytes may bring promising future for the therapy of ovarian cancer.
06 May 2023Submitted to Cancer Reports
09 May 2023Submission Checks Completed
09 May 2023Assigned to Editor
09 May 2023Review(s) Completed, Editorial Evaluation Pending
09 May 2023Reviewer(s) Assigned
24 May 2023Editorial Decision: Revise Major
18 Jun 20231st Revision Received
20 Jun 2023Submission Checks Completed
20 Jun 2023Assigned to Editor
20 Jun 2023Review(s) Completed, Editorial Evaluation Pending
20 Jun 2023Reviewer(s) Assigned
26 Jun 2023Editorial Decision: Accept