Impact of residential fine particulate matter exposure on acute chest
syndrome (ACS) admissions in children with sickle cell disease.
Acute chest syndrome (ACS) is a common lung complication associated with
high morbidity and mortality in children with sickle cell disease. The
role of fine particulate matter (PM 2.5) exposure in
admissions for ACS is limited. We assessed residential level PM
2.5 exposure in a case-crossover study of 503 patients
admitted to Texas Children’s Hospital between 2010 and 2019 in Houston,
TX. We examined whether short-term PM 2.5 exposure is
associated with increased odds of hospitalizations for ACS and found no
association between PM 2.5 exposures in the week
proceeding an ACS-related admission. However, larger studies are needed
to confirm or refute this finding.