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Impact of residential fine particulate matter exposure on acute chest syndrome (ACS) admissions in children with sickle cell disease.
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  • Jahnavi Gollamudi,
  • Amal Rammah,
  • Shaniqua Johnson-Anum,
  • Elaine Symanski,
  • Jonathan Flanagan
Jahnavi Gollamudi
University of Cincinnati Department of Internal Medicine

Corresponding Author:[email protected]

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Amal Rammah
Baylor College of Medicine
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Shaniqua Johnson-Anum
Baylor College of Medicine Department of Pediatrics
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Elaine Symanski
Baylor College of Medicine
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Jonathan Flanagan
Baylor College of Medicine Department of Pediatrics
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Abstract

Acute chest syndrome (ACS) is a common lung complication associated with high morbidity and mortality in children with sickle cell disease. The role of fine particulate matter (PM 2.5) exposure in admissions for ACS is limited. We assessed residential level PM 2.5 exposure in a case-crossover study of 503 patients admitted to Texas Children’s Hospital between 2010 and 2019 in Houston, TX. We examined whether short-term PM 2.5 exposure is associated with increased odds of hospitalizations for ACS and found no association between PM 2.5 exposures in the week proceeding an ACS-related admission. However, larger studies are needed to confirm or refute this finding.