loading page

Prognostic, diagnostic and clinicopathological roles of tsRNAs: a meta-analysis in breast cancer
  • +4
  • Lujue Gao,
  • Sixu Zhu,
  • Yingyi Wei,
  • Huawei Meng,
  • Jing Gu,
  • Hao Zhang,
  • Lijuan Dai
Lujue Gao
Nanjing University of Traditional Chinese Medicine
Author Profile
Sixu Zhu
Nanjing University of Traditional Chinese Medicine
Author Profile
Yingyi Wei
Nanjing University of Traditional Chinese Medicine
Author Profile
Huawei Meng
Nanjing University of Traditional Chinese Medicine
Author Profile
Jing Gu
Nanjing University of Traditional Chinese Medicine
Author Profile
Hao Zhang
Nanjing University of Traditional Chinese Medicine
Author Profile
Lijuan Dai
Nanjing University of Traditional Chinese Medicine

Corresponding Author:[email protected]

Author Profile

Abstract

Breast cancer (BC) is one of the most common malignancies in women and the leading cause of cancer-related death in women. The newly emerged non-coding RNAs tsRNAs (tRNA-derived small RNAs) play an important role in the occurrence and development of BC. The purpose of this study was to comprehensively evaluate the prognostic, diagnostic and clinicopathological roles of tsRNAs in BC. Through literature screening, a total of 13 BC-related tsRNA studies were included in this meta-analysis, all of which passed quality assessment. Prognostic studies showed upregulated tsRNAs to be associated with poor survival outcomes (HR=1.64, 95%CI: 1.51-1.77) and downregulated tsRNAs to be associated with better outcomes (HR=0.58, 95%CI: 0.50-0.68). Results of diagnostic studies showed a combined sensitivity of 72% (95%CI: 68%-76%) and combined specificity of 64% (95%CI: 61-67%); the AUC was 0.72 (95%CI: 0.68-0.75) and the DOR 4.62 (95%CI: 3.76-5.68). Finally, correlation analysis of clinicopathological features showed that downregulation of tsRNAs correlated significantly with age, TNM stage and lymphatic metastasis. Sensitivity analysis and publication bias showed no significant difference. In conclusion, BC-associated tsRNAs are closely related to the prognosis and clinicopathological features of patients with this disease and can be used to assist in early diagnosis of BC. Therefore, tsRNAs are potential targets for the diagnosis and treatment of BC.