The process of antiviral response is a complex and vast process
involving the interplay of multiple signaling pathways, leading to the
production of cytokines that coordinate the immune response. Recently,
O-GlcNAcylation has been found to play a role in antiviral responses,
especially against RNA viruses. Increased glucose uptake or the
regulation of key proteins in its pathway following infection happen to
induce O-GlcNAcylation. In humoral immunity, O-GlcNAcylation is
responsible for the maturity and migration of immune cells to infected
sites. Interestingly, these functions are context-dependent and may pose
“friend” and/or “foe” effects to the virus as well as the cell/body.
In this study, I examine existing knowledge of O-GlcNAcylation and its
signaling in relation to glucose metabolism and the coordination of
antiviral innate and adaptive immunity for and against viral infection.