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Physicochemical Understanding of Biomineralization by Molecular Vibrational Spectroscopy: From Mechanism to Nature
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  • Hao Liu,
  • Hui Jiang,
  • Xiaohui Liu,
  • Xuemei Wang
Hao Liu
Southeast University
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Hui Jiang
Southeast University
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Xiaohui Liu
Southeast University
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Xuemei Wang
Southeast University

Corresponding Author:[email protected]

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The process and mechanism of biomineralization and relevant physicochemical properties of mineral crystals are remarkably sophisticated multidisciplinary fields that include biology, chemistry, physics, and materials science. The components of the organic matter, structural construction of minerals, and related mechanical interaction, etc., could help to reveal the unique nature of the special mineralization process. Herein, the paper provides an overview of the biomineralization process from the perspective of molecular vibrational spectroscopy, including the physicochemical properties of biomineralized tissues, from physiological to applied mineralization. These physicochemical characteristics closely to the hierarchical mineralization process include biological crystal defects, chemical bonding, atomic doping, structural changes, and content changes in organic matter, along with the interface between biocrystals and organic matter as well as the specific mechanical effects for hardness and toughness. Based on those observations, the special physiological properties of mineralization for enamel and bone, as well as the possible mechanism of pathological mineralization and calcification such as atherosclerosis, tumor micro mineralization, and urolithiasis are also reviewed and discussed. Indeed, the clearly defined physicochemical properties of mineral crystals could pave the way for studies on the mechanisms and applications.
16 Apr 2023Submitted to Exploration
21 Apr 2023Submission Checks Completed
21 Apr 2023Assigned to Editor
24 Apr 2023Reviewer(s) Assigned
30 Apr 2023Review(s) Completed, Editorial Evaluation Pending
05 May 2023Editorial Decision: Revise Major
10 May 20231st Revision Received
10 May 2023Submission Checks Completed
10 May 2023Assigned to Editor
13 May 2023Reviewer(s) Assigned
15 May 2023Review(s) Completed, Editorial Evaluation Pending
25 Jun 2023Editorial Decision: Accept