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Structure of PD1 and its Mechanism in the Treatment of autoimmune diseases
  • Arezoo Hosseini,
  • Mahdi Rezaei
Arezoo Hosseini
Kobe University Graduate School of Medicine School of Medicine Division of Molecular and Cellular Bio

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Mahdi Rezaei
Islamic Azad University Tabriz Branch
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PD-1 and CTLA-4 can play an important role in addressing the issue of autoimmune diseases. PD-1 is a transmembrane glycoprotein expressed on T, B, and Dentric cells. This molecule functions as a checkpoint in T cell proliferation. Ligation of PD-1 with its ligands stimulates the production of IL-2, IL-7, IL-10, and IL-12 as well as other cytokines, which can inhibit cell proliferation and inflammation. Today, scientists attempt to protect against autoimmune diseases by PD-1 inhibitory signals. In this review, we discuss the structure, expression, and signaling pathway of PD-1. In addition, we discuss the importance of PD-1 in regulating several autoimmune diseases, reflecting how manipulating this molecule can be an effective method in the immunotherapy of some autoimmune diseases.
08 Apr 2023Submitted to Cell Biochemistry & Function
20 Apr 2023Submission Checks Completed
20 Apr 2023Assigned to Editor
20 Apr 2023Review(s) Completed, Editorial Evaluation Pending
23 Apr 2023Reviewer(s) Assigned
11 Jun 2023Editorial Decision: Revise Major
28 Jun 20231st Revision Received
28 Jun 2023Submission Checks Completed
28 Jun 2023Assigned to Editor
28 Jun 2023Review(s) Completed, Editorial Evaluation Pending
28 Jun 2023Reviewer(s) Assigned
08 Jul 2023Editorial Decision: Accept