loading page

Preparation of betaine injection and its therapeutic effect on pulmonary arterial hypertension
  • +4
  • Tian Xia,
  • Hui Liu,
  • Cong Li,
  • Siyun Liu,
  • Ping Ma,
  • Qingbin Xu,
  • Ru Zhou
Qingbin Xu
Author Profile
Ru Zhou

Corresponding Author:[email protected]

Author Profile


Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by elevated pulmonary pressure, right ventricular failure (RVF) and ultimately death. Aggressive treatment of RVF is considered the most important therapeutic strategy. In this study, betaine injection was prepared and characterized by various techniques. The therapeutic efficacy of gavage (I.G.), nebulized inhalation (Inh.) and intravenous (I.V.) injections was evaluated comprehensively in terms of pharmacokinetics, tissue distribution and pharmacodynamics using three different methods of administration. The results of pharmacokinetic demonstrated that Inh. betaine injection significantly prolonged the half-life of the drug, increased its internal circulation time and increased Inh. administration significantly improved the pharmacokinetics of betaine compared to I.G. and I.V. administration. Combined with biodistribution experiments verified that betaine formulation could accumulate in lung tissue via Inh. The results of pharmacodynamic further confirmed that right ventricular systolic pressure (RVSP), mean pulmonary artery pressure (mPAP) and right ventricular hypertrophy index (RVHI) were increased in the model group and that betaine prepared by Inh. was able to suppress this increase to levels similar to those observed in the control group. Consequently, Inh. administration would be a promising strategy for the treatment of PAH-induced RVF.
23 Mar 2023Submitted to Basic & Clinical Pharmacology & Toxicology
27 Mar 2023Review(s) Completed, Editorial Evaluation Pending
27 Mar 2023Submission Checks Completed
27 Mar 2023Assigned to Editor
30 Mar 2023Reviewer(s) Assigned
20 Apr 2023Editorial Decision: Revise Major
05 Jun 20231st Revision Received
06 Jun 2023Assigned to Editor
06 Jun 2023Submission Checks Completed
06 Jun 2023Review(s) Completed, Editorial Evaluation Pending
12 Jun 2023Reviewer(s) Assigned
07 Jul 2023Editorial Decision: Revise Major
09 Sep 20232nd Revision Received
11 Sep 2023Review(s) Completed, Editorial Evaluation Pending
11 Sep 2023Submission Checks Completed
11 Sep 2023Assigned to Editor
11 Sep 2023Reviewer(s) Assigned
10 Oct 2023Editorial Decision: Revise Major
01 Nov 20233rd Revision Received
01 Nov 2023Assigned to Editor
01 Nov 2023Submission Checks Completed
01 Nov 2023Review(s) Completed, Editorial Evaluation Pending
02 Nov 2023Reviewer(s) Assigned
21 Nov 2023Editorial Decision: Accept