Clinical characteristics, treatment, and survival outcome of ependymoma
Objectives: The treatment modalities of ependymoma in infants
remains controversial. Postoperative adjuvant radiotherapy (RT) could
prolong the overall survival but has the potential to affecting nervous
system development in infants. The role of adjuvant chemotherapy (CT) in
prolonging overall survival for infants with ependymoma is still
unclear. Therefore, we designed this study to explore the effect of
treatment modalities on survival time of infants with ependymoma.
Methods: A total of 72 infants with ependymoma from the
Surveillance, Epidemiology, and End Results (SEER) database in this
retrospective analysis. Univariate and multivariate Cox proportional
hazard models were adopted to determine hazard ratios and to compare
overall survival. Results: Among 72 infants with ependymoma, 35
were male (48.6%) and 37 were female (51.4%). The 5-year overall
survival of all patients was 67.0%. 46 infants (63.9%) received gross
total resection (GTR), 20 (27.8%) received subtotal resection (STR),
and 6 (8.3%) did not receive surgical resection or only autopsy. 21
infants (29.2%) received RT, and 45 (62.5%) received CT. Multivariate
analysis revealed that patients accepted surgical resection (No vs GTR,
P < 0.001; No vs STR, P = 0.026) and chemotherapy (No vs Yes,
P = 0.024) are the independent prognostic factors for overall survival.
Conclusion: Treatment modality is associated with survival time
in infants with ependymoma. The extent of resection and CT were
independent prognostic factors for infants with ependymoma.