C-Glycosides are critical, naturally occurring products and medicinal
candidates, and extensive efforts have been made to explore efficient
approaches for creating C-glycosidic bonds. Transition-metal-catalysis,
particularly nickel-catalyzed C-glycosylation reactions constitute a
promising strategy. However, achieving a stereoselective synthesis of α-
and β-C-glycosides has been a long-standing challenge. To address this
problem, a variety of nickel-mediated strategies have been developed.
This review highlights recent developments in the nickel-catalyzed
diastereoselective C-glycosylation reactions and briefly summarizes the
mechanistic understandings of these methods.