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Clinical Outcome and Prognostic Factors in Patients with Malign Minor and Major Salivary Gland Tumors of Head and Neck
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  • Ozlem Ozkaya Akagunduz,
  • Kerem Ozturk,
  • Nima Ghahramani,
  • Tayfun Hidimoglu,
  • Suleyman Eroglu,
  • Ali Veral,
  • Göksel Turhal,
  • Nurullah Serdar Akyildiz,
  • Mustafa Esassolak
Ozlem Ozkaya Akagunduz
Ege University Faculty of Medicine

Corresponding Author:[email protected]

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Kerem Ozturk
Ege University Faculty of Medicine
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Nima Ghahramani
Ege University Faculty of Medicine
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Tayfun Hidimoglu
Ege University Faculty of Medicine
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Suleyman Eroglu
Ege University Faculty of Medicine
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Ali Veral
Ege University Faculty of Medicine
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Göksel Turhal
Ege University Faculty of Medicine
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Nurullah Serdar Akyildiz
Ege University Faculty of Medicine
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Mustafa Esassolak
Ege University Faculty of Medicine
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Abstract

Purpose: This study evaluated the outcome of prognostic features and survival results of the major and minor malignant salivary gland carcinoma (MSGC) histopathologies. Materials and Methods: One hundred-forty patients with major/minor MSGC were registered in databases from 2004 to 2019. The median age of the patients was 57 (18-89). Major MSGC was diagnosed in 81 patients and mostly in the parotid gland (49%). Minor MSGC was diagnosed in 59 patients and often on the hard palate (19%). The most common histopathology is mucoepidermoid carcinoma (MEC)(47%) in major MSGC and adenoid cystic carcinoma (ACC) in minör MSGC (31%). Major MSGC was most diagnosed in the early stages, while the minor MSGC was diagnosed in the advanced stages. Results: Median follow-up is 73 months (5-197). The ten year local control (LC) and the distant metastasis free survival (DMFS) rates were 85% and 76%, respectively. The overall survival rate was 79% (10 years). The local control rates were statistically different in the patients with R1-R2 diseases (p=0.039) and advanced T and N stages (p=0.05, p=0.022, respectively). The presence of microscopic perineural invasion (PNI) was not significant in local recurrence in patients with ACC. Distant metastasis rates were statistically increased in patients with advanced tumor and nodal stages (p=0.031, p=0.003, respectively), R1-R2 disease (p=0.027), high grade (p=0.048), PNI (p=0.006). Conclusions: Advanced tumor and nodal stage, high tumor grade, and surgical margin status are strongly correlated with the worse oncological outcomes. The prognostic significance of microscopic PNI has not yet been clarified.