The effects of accident pregnancy CHB patients’ reproductive age on
their offspring during entecavir antiviral therapy: an observational
Background The study aimed to investigate the effects of accident
pregnancy CHB (Chronic Hepatitis B) patients’ reproductive age on their
offspring during entecavir (ETV) antiviral therapy. Methods We
retrospectively enrolled 112 couples were divided into observational and
control groups. 53 couples who had accident pregnancies while receiving
long-term ETV antiviral medication were recruited for the observational
group. The control group comprised 59 couples who became pregnant
accidentally while receiving long-term TDF antiviral treatment. All
mothers persisted in their pregnancies in the observational group, and
ETV was promptly replaced with TDF. Every mother remained pregnant and
continued to use TDF in the control group. Results The maternal and baby
safety profiles, including the prevalence of congenital disabilities,
were comparable across the observational and control groups at delivery.
In addition, no unusual indications or symptoms of the newborns were
noted during the follow-up intervals of 28, 48, and 96 weeks postpartum.
Conclusions Initiating ETV or TDF in early and middle pregnancy seems to
be safe for both mothers and infants. Important data from our
investigation support using ETV in early-mid gestational accident
pregnancies and the prompt substitution of TDF antiviral medication for
ETV. The pregnancy was not needed to be terminated.