Objective: To summarize the best evidence on the management of aerosol inhalation in children, and to provide reference for clinical practice. Methods: According to the ‘6S’ model of evidence resources, systematically searched British Medical Journal Best Practice (BMJ Best Practice), PubMed, American Clinical Guidelines Network (AHRQ), Scottish Intercollegiate Guidelines Network Guidelines Library (SIGN), and international guideline books. Library (GIN), Canadian Medical Association Clinical Practice Guidelines Repository (CMACPG), National Health and Medical Research Council Australia Guidelines Repository (NHMRC), National Institute for Health and Clinical Excellence Guidelines Repository (NICE), Evidence-Based Medicine Library (Cochrane Library), Netherlands Medical Abstracts Database (Embase), Ovid-Medline, EBSCO-CINAHL, JBI, Registered Nurses Association of Ontario, European Society of Respiratory Therapy, American Society of Respiratory Therapy, Wanfang, VIP, CNKI, Medlive(Yi Mai Tong), and Sino Med. The literature resources include clinical practice guidelines, expert consensus, evidence summary, and systematic review of children’s aerosol inhalation. Two researchers independently conducted quality evaluation, evidence extraction, and evidence integration of the literature. Results: A total of 11 papers were included, including 2 guidelines, 6 expert consensus papers, 1 systematic review, and 2 evidence summaries; finally, 6 evidence themes were formed: principles of aerosol drug use, selection of aerosol devices, effects of aerosolization factors of nebulization effect, management during nebulization treatment, infection control; a total of 34 evidence opinions. Conclusion: The summarized evidence on children’s aerosol inhalation can be applied to clinical practice according to the actual clinical situation, promote the standardized management of children’s aerosol inhalation, and improve the therapeutic effect of aerosolization.