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PET and MRI Imaging in Alzheimer’s Disease:Potential Mechanisms and Findings
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  • Yan Zhang,
  • Chenpeng Zhang,
  • Hongda Shao,
  • Jianjun Liu
Yan Zhang
Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital
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Chenpeng Zhang
Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital
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Hongda Shao
Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital
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Jianjun Liu
Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital

Corresponding Author:[email protected]

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Abstract

Alzheimers disease (AD) is a common neurodegenerative disease. The histopathological changes of AD include amyloid β-protein (Aβ) deposition, tau tangles, neuroinflammation and neurodegeneration. Some of the pathological changes could be shown in vivo by positron emission tomography (PET) and magnetic resonance imaging (MRI) biomarkers which play a key role in diagnosing AD. Fluorodeoxyglucose positron emission tomography (FDG-PET) can reflect and predict dysfunction. Aβ-PET was sensitive for the diagnosis of early AD but cannot distinguish the severity of AD. Tau-PET can compensate for the deficiency of Aβ-PET. Tau tangles were positively correlated with the severity of AD, and also associated with cognitive impairment. Probes targeting neuroinflammation of AD have been developed, but further study is needed to validate its effectiveness. Conventional MRI performs high tissue contrast that can show structural changes and has been routinely applied in clinical practice, such as evaluation of cerebral atrophy. Advanced MRI sequences (such as DTI、ASL、MRS、BOLD and QSM) that can provide additional information beyond structure that includes brain microstructure, blood perfusion, metabolite concentration, brain activity, connections and networks between brain regions, iron deposition, etc. The integrated PET and MR may improve the diagnostic efficiency of AD.
28 Feb 2023Submitted to View
01 Mar 2023Review(s) Completed, Editorial Evaluation Pending
01 Mar 2023Submission Checks Completed
01 Mar 2023Assigned to Editor
03 Mar 2023Reviewer(s) Assigned
24 Mar 2023Editorial Decision: Revise Minor
05 Apr 20231st Revision Received
18 Apr 2023Submission Checks Completed
18 Apr 2023Assigned to Editor
18 Apr 2023Review(s) Completed, Editorial Evaluation Pending
20 Apr 2023Editorial Decision: Accept