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High prevalence of blaCTX-M-15 type extended-spectrum beta-lactamases in Gambian hooded vultures (Necrosyrtes monachus) – a threatened species with substantial human interaction
  • Hanna Woksepp,
  • Fagimba Camara,
  • Jonas Bonnedahl
Hanna Woksepp
Region Kalmar lan

Corresponding Author:[email protected]

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Fagimba Camara
the West African Birds Study Association
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Jonas Bonnedahl
Linköping University
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One hundred fecal samples from hooded vultures in the Gambia (Banjul area) were investigated for the presence of bacteria with extended-spectrum cephalosporin- (ESBL/AmpC), carbapenemases, and colistin resistance. No Enterobacteriales carrying carbapenemases or resistance against colistin were detected. Fifty-four ESBL-producing Escherichia coli and five ESBL-producing Klebsiella pneumoniae isolates were identified in 52 of the samples, of which 52 E. coli and 4 K. pneumoniae yielded passed sequencing results. Fifty of the E. coli had ESBL phenotype and genotype harboring blaCTX-M genes, of which 88.5% (n=46) were the blaCTX-M-15 gene, commonly found on the African continent. Furthermore, the genetic context around blaCTX-M-15 was similar between isolates, being co-localized with ISKpn19. In contrast, cgMLST analysis of the E. coli harboring ESBL genes revealed a genetic distribution over a large fraction of the currently known existing E. coli populations in the Gambia. Hooded vultures in the Gambia thus have a high ESBL E. coli-prevalence (>50%) with low diversity regarding key resistance genes. Furthermore, given the urban presence and frequent interactions between hooded vultures and humans, data from this study implies hooded vultures as potential vectors contributing to the further dissemination of antibiotic-resistance genes.
29 Sep 2022Submitted to MicrobiologyOpen
03 Oct 2022Submission Checks Completed
03 Oct 2022Assigned to Editor
03 Oct 2022Reviewer(s) Assigned
21 Dec 2022Review(s) Completed, Editorial Evaluation Pending
21 Dec 2022Editorial Decision: Revise Minor
10 Feb 20231st Revision Received
11 Feb 2023Submission Checks Completed
11 Feb 2023Assigned to Editor
15 Feb 2023Review(s) Completed, Editorial Evaluation Pending
15 Feb 2023Editorial Decision: Revise Minor
17 Feb 20232nd Revision Received
20 Feb 2023Submission Checks Completed
20 Feb 2023Assigned to Editor
21 Feb 2023Review(s) Completed, Editorial Evaluation Pending
23 Feb 2023Editorial Decision: Accept