Abstract Background: Nasal septal perforations (NSP) cause a variety of bothersome symptoms for patients, and when medical management fails, surgical repair is indicated. Objective: This study examines the efficacy of a NSP repair method utilizing superficial or deep temporal fascia and a polydiaxonone (PDS) plate scaffold to the prior repair method of a pedicled anterior ethmoid mucosal flap. Methods: A retrospective review of patients who underwent NSP repair at a tertiary academic medical center from 2016-2021. Results: The most common etiologies for NSP were prior nasal surgery, digital trauma, and chronic epistaxis. Compared to the previous repair group with local flaps, the temporalis fascia and PDS plate group had significantly higher rates of complete closure for perforations of all sizes and a lower incidence of revision surgery. Patients also reported improved resolution of symptoms after repair with this new method. Conclusion: The use of temporalis fascia with a PDS plate is a promising surgical method for repair of NSP, regardless of size or etiology. Keywords: septal perforation, polydiaxonone, temporalis