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Enhancement of SARS-CoV-2 infection and growth by an ACE2-specific monoclonal antibody
  • Guangxiang Luo
Guangxiang Luo
The University of Alabama at Birmingham Department of Microbiology

Corresponding Author:[email protected]

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SARS-CoV-2 causes COVID-19 pandemic and continues to pose a threat to global public health through genetic mutation. In this study, we have found that an ACE2-specific monoclonal antibody at low concentration was able to greatly enhance SARS-CoV-2 infection and growth in cell culture. Strikingly, it promotes SARS-CoV-2 plaque formation, resulting in accurate titration of different SARS-CoV-2 variants, particularly the newly emerged Omicron variants, which otherwise cannot be determined by standard plaque assays. Quantification of infectious titers of the newly emerged variants will facilitate the development and evaluation of vaccines and antiviral drugs against SARS-CoV-2.
23 Feb 2023Submitted to Journal of Medical Virology
23 Feb 2023Submission Checks Completed
23 Feb 2023Assigned to Editor
23 Feb 2023Review(s) Completed, Editorial Evaluation Pending
23 Feb 2023Reviewer(s) Assigned
24 Feb 2023Editorial Decision: Revise Minor
10 Mar 20231st Revision Received
15 Mar 2023Submission Checks Completed
15 Mar 2023Assigned to Editor
15 Mar 2023Review(s) Completed, Editorial Evaluation Pending
16 Mar 2023Editorial Decision: Accept