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An update on recent developments and highlights in food allergy
  • +3
  • Arielle Locke,
  • Lisa Hung,
  • Julia Upton,
  • Liam O'Mahony,
  • Jennifer Hoang,
  • Thomas Eiwegger
Arielle Locke
University of Galway
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Lisa Hung
SickKids Research Institute
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Julia Upton
SickKids Research Institute
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Liam O'Mahony
National University of Ireland
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Jennifer Hoang
SickKids Research Institute
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Thomas Eiwegger
SickKids Research Institute

Corresponding Author:[email protected]

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While both the incidence and general awareness of food allergies is increasing, the variety and clinical availability of therapeutics remain limited. Therefore, investigations into the potential factors contributing to the development of food allergy and the mechanisms of natural tolerance or induced desensitization are required. In addition, a detailed understanding of the pathophysiology of food allergies is needed to generate compelling, enduring, and safe treatment options. New findings regarding the contribution of barrier function, the effect of emollient interventions, mechanisms of allergen recognition, and the contributions of specific immune cell subsets through rodent models and human clinical studies provide novel insights. With the first approved treatment for peanut allergy, the clinical management of food allergy is evolving towards less intensive, alternative approaches involving fixed doses, lower maintenance dose targets, co-administration of biologicals, adjuvants, and tolerance-inducing formulations. The ultimate goal is to improve immunotherapy and develop precision-based medicine via risk phenotyping allowing optimal treatment for each food-allergic patient.
17 Feb 2023Submitted to Allergy
17 Feb 2023Submission Checks Completed
17 Feb 2023Assigned to Editor
17 Feb 2023Review(s) Completed, Editorial Evaluation Pending
18 Feb 2023Reviewer(s) Assigned
06 Mar 2023Editorial Decision: Revise Minor
07 Apr 20231st Revision Received
07 Apr 2023Submission Checks Completed
07 Apr 2023Assigned to Editor
07 Apr 2023Review(s) Completed, Editorial Evaluation Pending
13 Apr 2023Reviewer(s) Assigned
19 Apr 2023Editorial Decision: Accept