Alkaline suppress plant growth because Fe is insolubilized. Swiss chard ( Beta vulgaris L.) grown in alkaline condition with high Na levels such as aquaculture wastewater in dry lands take up Fe and grows well, but the mechanisms of Fe uptake and growth promotion by Na are still unknown. Here, we investigated the effects of alkaline pH, Fe deficiency, and high salt on Fe uptake, translocation, and distribution in salt tolerant epazote ( Dysphania ambrosioides L.), natrophilic Swiss chard, and euhalophyte romerito ( Suaeda edulis Flores Olv. & Noguez). These three species were grown for 6 days in 8 treatments at pH 5.0 or 8.2, 0.02 or 2.00 ppm Fe and 5 or 100 mM NaCl. We measured changes in medium pH, ferric-chelate reductase (FCR) activity in roots, Fe contents, and Na contents. Root ferric-chelate reductase activity was similar at pH 5.0 and pH 8.2 in all species. At high pH and salt, the medium pH in Swiss chard and romerito decreased markedly with time, and this acidification solubilized Fe and Fe uptake tended to increase. For adjusting the cation–anion balance, uptake of large amounts of Na ⁺ could promote H ⁺ release, resulting in the medium acidification. High salt increased the distribution of Fe to petioles in Swiss chard and to leaves in romerito, suggesting that Na contributes to the translocation of Fe from the root apoplast upward to the shoot. The facts that Na intensifies Fe uptake and translocation to the shoots could be a mechanism to promote the growth of Swiss chard and romerito at alkaline condition.