Histologic Features and Decreased Lung FOXF1 Gene Expression in Severe
Bronchopulmonary Dysplasia without a Genetic Diagnosis of Alveolar
Severe BPD can be associated with clinical and histologic features that
are similar to ACD without evidence of FOXF1 genetic disease.
Importantly, lung FOXF1 and TMEM100 gene expression is markedly
decreased in severe BPD, suggesting that impaired FOXF1 signaling may
contribute to abnormal lung growth and refractory pulmonary hypertension