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A chitosan based hydrogel containing zinc oxide nanoparticles as a carrier for improving antibacterial activity and controlling the release of antibiotics
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  • Ali Rastegari,
  • Fatemeh Hasanshakir ,
  • Zohreh Mohammadi,
  • Fatemeh Saadatpor,
  • Fatemeh Moraffah
Ali Rastegari
Iran University of Medical Sciences

Corresponding Author:rastegari.a@iums.ac.ir

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Fatemeh Hasanshakir
Iran University of Medical Sciences
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Zohreh Mohammadi
Iran University of Medical Sciences
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Fatemeh Saadatpor
Tehran University
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Fatemeh Moraffah
Tehran University of Medical Sciences
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Microbial infections are considered as one of the most important concerns of the world community. Developing drug delivery systems based on formulation of nanoparticles with antimicrobial agents have shown beneficial effectiveness against microbial infections and related antimicrobial resistance. In this study we prepared and characterized a chitosan based hydrogel loaded with zinc oxide nanoparticles for controlling the release of vancomycin and also improving its antibacterial effect. Characterization studies demonstrated that the developed biopolymeric hydrogel was able to sustained and controlled the release of vancomycin in response to acidic media for 96 hours. Furthermore, antimicrobial studies showed siginificant and efficient antibacterial activity of prepared hydrogel against S. aureus and P. aeruginosa. Based on obtained results, it can be concluded that the prepared chitosan hydrogel containing ZnO nanoparticles has a desirable activity for controlling the release of vancomycin and improving its antibacterial properties.
02 Feb 2023Submitted to Micro & Nano Letters
14 Feb 2023Assigned to Editor
14 Feb 2023Submission Checks Completed
23 Feb 2023Reviewer(s) Assigned