Palladium-Catalyzed Skeletal Reorganisation of Cyclobutanones Invoving
Successive C−C Bond/C−H Bond Cleavage
The utilization of cyclobutanones as the synthon in transition metal
catalysis has been made great success. Because C(carbonyl)−C bond of
cyclobutanones can be cleaved through strain release. Despite those
advancements, the main catalysts in literature are Rh catalysts or Ni
catalysts and the reaction with C–H bond is still underdeveloped.
Herein, we realized the first palladium-catalyzed skeletal
reorganisation of cyclobutanones invoving successive cleavage of
C(carbonyl)−C bonds and C−H bond cleavage, which con-stitutes an rapid
access to diverse indanones.