Association Between Aspirin Resistance and Blood Lipid Profile in
Patients of Ischemic Stroke: A Meta-Analysis
In ischemic stroke patients, aspirin resistance has been linked to an
altered lipid profile. This study was undertaken to explore the
association of blood lipid profiles with aspirin resistance in ischemic
stroke patients. Relevant studies published before November 2022 in
PubMed, Medline, EMBASE, and Google Scholar were chosen for this study.
Random effects models were used to assess pooled standardized mean and
standard deviation (SD) with a 95% confidence interval (CI). RevMan 5
and STATA version 13.0 software were used for statistical analysis.
Subjects from eight studies consisting of aspirin resistance and
sensitive data were considered in this meta-analysis. Our findings
suggested a significant association between the elevated levels of TG in
Aspirin resistance groups as compared to non-resistance (SMD 0.83, 95%
CI 0.30 to 1.95, p-value < 0.001). However, the meta-influence
analysis suggested no significant association when a study with a large
effect size was excluded. The results of our comprehensive meta-analysis
suggest none of the lipid parameters were significantly associated with
aspirin resistance. Further studies might be required to support the
findings of this meta-analysis.