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  • Marieke Verkleij,
  • Anna Georgiopoulos,
  • Heleen Barendrecht,
  • Deborah Friedman
Marieke Verkleij
Emma Kinderziekenhuis Amsterdam UMC

Corresponding Author:[email protected]

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Anna Georgiopoulos
Massachusetts General Hospital Department of Psychiatry
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Heleen Barendrecht
Emma Kinderziekenhuis Amsterdam UMC
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Deborah Friedman
Massachusetts General Hospital Department of Psychiatry
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Background: eHealth CF-CBT is the first digital mental health intervention for depression/anxiety in adults with cystic fibrosis (awCF); an 8-session therapist-guided internet-delivered program that was developed in English and Dutch with stakeholder input and evaluation indicating high acceptability and usability. Methods: Dutch eHealth CF-CBT was piloted in awCF with mild-moderate symptoms of depression and/or anxiety. Feasibility, usability, acceptability, and preliminary efficacy were assessed, measuring pre-post changes in depression (PHQ-9), anxiety (GAD-7), perceived stress (PSS) and health-related quality of life (CFQ-R). Results: All participants (n=10, 7 female, mean age 29 (range 21-43), mean FEV1 71%pred (range 31-115)) completed all sessions. Patient-rated feasibility, usability and acceptability of eHealth CF-CBT was positive on validated scales, as were qualitative assessments of content and format. GAD-7 improved in 90% of participants; in 50% by ≥ the minimally important difference (MID) of 4 points. PHQ-9 improved in 90%; 40% by ≥ the MID of 5. PSS improved in 80%. CFQ-R improved in the domain Health Perceptions (70%). Conclusions: eHealth CF-CBT demonstrated feasibility, usability, acceptability and promising preliminary efficacy in this pilot trial with Dutch awCF with mild to moderate symptoms of depression and anxiety.
30 Jan 2023Submitted to Pediatric Pulmonology
30 Jan 2023Submission Checks Completed
30 Jan 2023Assigned to Editor
30 Jan 2023Review(s) Completed, Editorial Evaluation Pending
04 Feb 2023Reviewer(s) Assigned
25 Feb 2023Editorial Decision: Revise Minor
12 Mar 20231st Revision Received
21 Mar 2023Submission Checks Completed
21 Mar 2023Assigned to Editor
21 Mar 2023Review(s) Completed, Editorial Evaluation Pending
21 Mar 2023Reviewer(s) Assigned
21 Apr 2023Editorial Decision: Accept