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Scrub typhus diagnostics: An overview
  • +5
  • Cheryl Lynnette S,
  • Trishna Bora,
  • Susmitha Perumalla,
  • Karthick G,
  • Babban Jee,
  • Gaurav Batra,
  • Khan SA,
  • Prakash JAJ
Cheryl Lynnette S
Department of Clinical Microbiology, Christian Medical College
Trishna Bora
Regional Medical Research Centre
Susmitha Perumalla
Department of Clinical Microbiology, Christian Medical College
Karthick G
Babban Jee
Department of Health Research (DHR), Department of General Medicine, Christian Medical College

Corresponding Author:

Gaurav Batra
Translational Health Science and Technology Institute
Khan SA
Department of Clinical Microbiology, Scientist-C, Department of Health Research (DHR), Postgraduate Institute of Medical Education and Research, Regional Medical Research Centre
Prakash JAJ
Department of Clinical Microbiology, Christian Medical College


Scrub typhus caused by Orientia tsutsugamushi is a vector-borne, zoonotic disease which is common in the tsutsugamushi triangle. Scrub typhus causes AUFI in patients with non-specific clinical features and is difficult to diagnose when the highly characteristic but not pathognomonic eschar is not seen. As the eschar is not always present, laboratory tests are needed for confirmation. Serological assays are the main stay of laboratory diagnosis of scrub typhus thus far. In this review, we present the salient clinical features and clinical algorithms suggestive of this disease that help in better selection of diagnostics. The various scrub typhus assays along with their advantages and disadvantages have also been discussed. Furthermore, we have also discussed the upcoming diagnostics, both serological and molecular assays which can be available in the near future.