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Therapeutic Potential of Tumor Treating Fields for Malignant Brain Tumors
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  • Youyou Zhou,
  • Xiaoqing Xing,
  • Jinyun Zhou,
  • Han Jiang,
  • Peili Cen,
  • Chentao Jin,
  • Yan Zhong,
  • Rui Zhou,
  • Jing Wang,
  • Mei Tian,
  • Hong Zhang
Youyou Zhou
Zhejiang University
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Xiaoqing Xing
Zhejiang University
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Jinyun Zhou
Zhejiang University
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Han Jiang
University of Macau
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Peili Cen
Zhejiang University
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Chentao Jin
Zhejiang University
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Yan Zhong
Zhejiang University
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Rui Zhou
Zhejiang University
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Jing Wang
Zhejiang University
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Mei Tian
Zhejiang University
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Hong Zhang
Zhejiang University

Corresponding Author:hzhang21@zju.edu.cn

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Abstract

Background Malignant brain tumors are among the most threatening diseases of the central nervous system, and despite increasingly updated treatments, the prognosis has not been improved. Tumor treating fields (TTFields) are an emerging approach in cancer treatment using intermediate-frequency and low-intensity electric field, and can lead to development of novel therapeutic options. Recent findings A series of biological processes induced by TTFields to exert anti-cancer effects have been identified, and applications of TTFields in oncology have been increasingly reported. This review addresses the mechanisms of TTFields and recent advances in the application of TTFields therapy in malignant brain tumors, especially in glioblastoma (GBM). Conclusions As a novel therapeutic strategies, TTFields have shown promising results in many clinical trials, especially in GBM, and continue to evolve. A growing number of patients with malignant brain tumors are being enrolled in ongoing clinical studies demonstrating that TTFields-based combination therapies can improve treatment outcomes.
18 Jan 2023Submitted to Cancer Reports
20 Jan 2023Assigned to Editor
20 Jan 2023Submission Checks Completed
20 Jan 2023Review(s) Completed, Editorial Evaluation Pending
21 Jan 2023Reviewer(s) Assigned