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The influence of disparities on intensive care outcomes in children with respiratory diseases: a systematic review
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  • Tahira Hussain,
  • Sarah van den Berg,
  • Kirsten Ziesemer,
  • Dick Markhorst,
  • Susanne Vijverberg,
  • Berber Kapitein
Tahira Hussain
Emma Childrens' Hospital UMC
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Sarah van den Berg
Emma Childrens' Hospital UMC
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Kirsten Ziesemer
Medical Library, Vrije Universiteit Amsterdam
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Dick Markhorst
Emma Childrens' Hospital UMC
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Susanne Vijverberg
Amsterdam UMC
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Berber Kapitein
Emma Childrens' Hospital UMC

Corresponding Author:[email protected]

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Context – The negative effects of socioeconomic, environmental and ethnic inequalities on childhood respiratory diseases are known in the development of persistent asthma and can result in adverse outcomes. However, little is known about the effects of these disparities on pediatric intensive care unit (PICU) outcomes in respiratory diseases. Objective – The purpose of this systematic review is to evaluate the literature on disparities in socioeconomic, environmental and ethnic determinants on PICU outcomes. We hypothesize that these disparities negatively influence the outcomes of children’s respiratory diseases at the PICU. Methods – A literature search (in PubMed, Embase.com and Web of Science Core Collection) was performed up to September 30, 2022. Two authors extracted the data and independently evaluated the risk of bias with appropriate assessment methods. Articles were included if the patients were below 18 years of age (excluding neonatal intensive care unit admissions), they concerned respiratory diseases and incorporated socioeconomic, ethnic or environmental disparities. Results – Of 8746 references reviewed, 15 articles were included; seven articles on the effect of socioeconomic status, five articles on ethnicity, one on the effect of sex and lastly two on environmental factors. All articles but one showed an unfavorable outcome at the PICU. Conclusion – Disparities in socioeconomic (such as a low-income household, public health insurance), ethnic and environmental factors (such as exposure to tobacco smoke and diet) have been assessed as risk factors for the severity of children’s respiratory diseases and can negatively influence the outcomes of these children at the PICU.
14 Jan 2023Submitted to Pediatric Pulmonology
16 Jan 2023Submission Checks Completed
16 Jan 2023Assigned to Editor
16 Jan 2023Review(s) Completed, Editorial Evaluation Pending
05 Mar 2023Reviewer(s) Assigned
11 Jun 2023Editorial Decision: Revise Minor
17 Jul 20231st Revision Received
19 Jul 2023Review(s) Completed, Editorial Evaluation Pending
19 Jul 2023Submission Checks Completed
19 Jul 2023Assigned to Editor
25 Jul 2023Editorial Decision: Accept