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A review of potential cardiac drug-drug interactions amongst patients presenting with cystic fibrosis exacerbation
  • Ismail Sooltan,
  • Firuza Dzhakhangirli,
  • Sudantha Bulugahapitiya
Ismail Sooltan
Leeds Teaching Hospitals NHS Trust

Corresponding Author:ismail.sooltan1@nhs.net

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Firuza Dzhakhangirli
Leeds Teaching Hospitals NHS Trust
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Sudantha Bulugahapitiya
Bradford Teaching Hospitals NHS Foundation Trust
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Drug-drug interactions inducing adverse drug reactions remain a significant, avoidable health risk to cystic fibrosis (CF) patients. With increasingly complex CF exacerbation treatment regimens being used, the risk of clinically important drug-drug interactions has in turn increased. Cardiovascular medications have reportedly been commonly implicated in severe CF exacerbation drug-drug related reactions. Therefore, knowledge of these potential drug-drug interactions is essential for improvement of medication safety and preventing patient harm. Drug-drug interactions can be classified into either pharmacokinetic or pharmacodynamic. This article, using the British National Formulary, details the drug-drug interactions between commonly prescribed CF exacerbation medications and cardiac medications. For each respective drug-drug interaction, the potential consequence, management strategy and interaction severity have been described.