Aims The aim of this study was to look at effectiveness of SET as a single session in the treatment of depression associated with PTSD. Method A cohort of 82 subjects were assessed using the Beck Depression Inventory at the start of the single-session and at the conclusion of the single-session. Single session SET consisting of recording baseline measures, administration of four clinical exercises, questionnaire administration and results analysis. Results Results of the tests (n=82) showed clinically significant therapeutic effects from SET in a single therapy session with 76.82% improvement. Conclusions Results for the in-person single shot two hour SET depression intervention demonstrated clinically significant impact on depression symptoms associated with PTSD.